Complete Natural Turmeric Matrix
From ancient days to present, Turmeric has been clinically proven to treat various inflammatory disorders. Turmeric and its active components support cognitive, cardiovascular, digestive, immune, muscle and joint health. The high antioxidant activity of curcuminoids is mainly responsible for turmeric’s powerful anti-inflammatory activity. But the major hurdle of these curcuminoids is poor bioavailability, thereby limiting turmeric’s full medicinal potential.
PNS technology is used to increase the bioefficacy and bioavailability turmeric by preserving the natural matrix of the product without any degradation of the active molecules.
PNS technology incorporates the polar and nonpolar compounds of the spice/herb of interest. The active molecules are well protected inside the polar- nonpolar matrix without any structural degradation.
PNS technology ensures the delivery of the active molecules at the specific site thereby ensuring the bioefficacy of the product. The recreation of the natural matrix also helps to increase the stability of the active molecules.
The matrix provides advantages such as enhanced physical stability, protection of the Curcuminoids from degradation in the body, controlled Curcuminoid release and biocompatibility.
Recently our partner scientists in India have conducted a double-blind, randomized controlled study evaluating the efficacy of Dr. D’s Ultra BioTurmeric as a support in Rheumatological conditions.
Thirty-six subjects were randomized in a 1:1:1 ratio to receive 250mg of the study product as the low dose Dr. D’s Ultra BioTurmeric, 500mg as the high-dose Dr. D’s Ultra BioTurmeric, and placebo (500mg of food grade starch) over a period of 3 months as one capsule twice daily 30min after meals. Dose setting of the study product was based on the bioavailability of the product compared to the 95% curcumin. Laboratory parameters as biomarkers of Rheumatological conditions included erythrocyte sedimentation rates (ESR), C-reactive protein (CRP), and rheumatoid factor (RF). Pregnancy tests were performed in women. A joint assessment was performed for a tender joint count (TJC), swollen joint count (SJC), and duration of morning stiffness. The study outcomes were evaluated using the American College of Rheumatology (ACR) response, Visual Analog Scale (VAS), C-reactive protein (CRP), Disease Activity Score 28 (DAS28), Erythrocyte Sedimentation Rate (ESR) and Rheumatoid Factor (RF) values. These observations were also confirmed by significant changes in ESR, CPR and RF values in patients receiving Dr. D’s Ultra BioTurmeric, as compared to baseline and placebo.
Efficacy assessment of ESR values
Both high dose and low dose treatment showed significant decrease in the ESR values, there by indicating the efficiency of Dr. D’s Ultra BioTurmeric in supporting rheumatological conditions.
ACR 20 Response
The severity of Rheumatological conditions is assessed on sections of the ACR scoring system. Each group were analysed for the number of tender joints and number of swollen joints, the assessment of pain, patient’s and physician’s global assessments of disease activity, and patient’s assessment of physical function. The mean ACR 20 values of both low dose and high dose treatment groups at the baseline were found to be 19 and 16 and at the end of treatment, the values were 65 and 68 respectively. Taking into account of the swollen and tender joints, the treatment groups supplemented with 500mg Dr. D’s Ultra BioTurmeric showed decrease of 85% and 88% respectively; where as low dose showed 80% and 78% respectively.
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